Argireline vs Retinol: Which should come first in your skincare routine?

As a skincare enthusiast, you may find yourself researching various ingredients and their effects on the skin. Two popular ingredients that often come up in discussions are argireline and retinol. While both have their benefits, the question of whether to use argireline before or after retinol has caused some confusion. Let’s explore the benefits of each ingredient and the best way to incorporate them into your skincare routine.

The Benefits of Argireline

Argireline is a peptide that works by inhibiting the neurotransmitters that cause facial muscles to contract. This results in a temporary reduction in the appearance of fine lines and wrinkles. Unlike Botox, argireline does not require injections and can be found in various skincare products.

Some people prefer to use argireline as an alternative to Botox or as a complement to other anti-aging ingredients. It is especially popular among those with sensitive skin who may experience irritation or adverse reactions to other anti-aging treatments.

The Benefits of Retinol

Retinol is a form of vitamin A that helps to speed up cell turnover, stimulate collagen production, and improve skin texture. It is often recommended for those looking to address concerns such as fine lines, wrinkles, and sun damage.

While retinol can be highly effective, it can also cause irritation and sensitivity. It is important to start with a low concentration and gradually increase usage over time. Those with sensitive skin may want to use a gentler form of retinol, such as retinyl palmitate.

Using Argireline and Retinol Together

While both argireline and retinol have their benefits, they work in different ways and thus can be used together in a skincare routine. However, it is important to follow a few guidelines to ensure their effectiveness and avoid irritation.

  • Start with retinol: Retinol should be applied first, as it is a more active ingredient that requires absorption into the skin. Wait at least 20-30 minutes after applying retinol before using any other products.
  • Use argireline sparingly: Argireline should be used sparingly, as too much can cause the skin to feel overly tight or dry. A pea-sized amount is typically enough for the entire face.
  • Apply argireline after retinol: Once your retinol has fully absorbed, you can apply your argireline-containing product. This will help to further reduce the appearance of fine lines and wrinkles.


In conclusion, both argireline and retinol can be highly effective anti-aging ingredients when used properly. When incorporating both into your routine, it is important to use retinol first and apply argireline sparingly afterwards. As always, it is important to listen to your skin and adjust your routine as needed.

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